Codeine is not recommended in adolescents with compromised respiratory perform for your treatment of cough and/or cold.
Sodium oxybate: concomitant administration of codeine and sodium oxybate could induce enhanced CNS melancholy and/or respiratory melancholy and/or hypotension.
If Females choose this drug during pregnancy, There's a hazard that their new child infants will expertise neonatal withdrawal syndrome.
Musculoskeletal and connective tissue Diseases: Uncontrolled muscle actions. Muscle mass rigidity may manifest just after high doses.
Write-up-operative use in youngsters There have already been experiences within the published literature that codeine specified put up-operatively in youngsters after tonsillectomy and/or adenoidectomy for obstructive sleep apnoea, brought about uncommon, but daily life-threatening adverse activities which include death (see also segment 4.
Codeine-containing solutions are contraindicated for postoperative discomfort management in youngsters who may have been through tonsillectomy and/or adenoidectomy.
These indicators may possibly show that you'll be an "ultra-rapid metabolizer of codeine". As a result, there is an excessive amount morphine in the human body and much more Uncomfortable side effects of morphine than typical. Small children might be especially sensitive to this influence. Do not give this medication to:
Dizziness, lightheadedness, or fainting may perhaps come about if you stand up all of a sudden click here from a lying or sitting down placement. Acquiring up bit by bit may perhaps assistance. Also, lying down for a while could decrease dizziness or lightheadedness. If this problem carries on or will get even worse, Check out using your medical doctor right away.
Discomfort affiliated with hyperalgesia tends to be much more diffuse compared to the pre-existing agony and less described in excellent. Signs or symptoms of hyperalgesia may well resolve with a reduction of opioid dose.
It works within the central anxious method plus the Mind to dam agony alerts to the rest of the overall body. It also lessens the anxiousness and anxiety brought on by discomfort.
Skin and subcutaneous tissue Problems: allergic reactions including skin rashes, click here urticaria, pruritus, sweating and facial oedema. Musculoskeletal and connective tissue Problems: Uncontrolled muscle mass movements. Muscle mass rigidity may perhaps manifest right after large doses.
Overuse or misuse could result in overdose and/or death. It's important that patients only use medicines which have been prescribed for them for the dose they have already been prescribed and don't give this drugs to any individual else.
Symptoms Central anxious procedure melancholy, including respiratory melancholy, may well build but is not likely to become significant unless other sedative agents are already co-ingested, like alcohol, or perhaps the overdose is extremely substantial. The triad of coma, pinpoint pupils and respiratory depression is considered indicative of opioid above dosage with dilation of your pupils happening as hypoxia develops.
Opioid analgesics might trigger gastric stasis all through labour, rising the risk of inhalation pneumonia from the mother.